Effect of melatonin on hematological indices in cyclophosphamide induced hematotoxicity in mice

Background: Cyclophosphamide use is often limited by associated hematotoxicity. This study investigated the effects of melatonin on haematological indices in cyclophosphamide-induced hematotoxicity mice. Methods: Ninety mice weighing between 20-25 gm were randomly divided equally into nine groups (A-I). Group A (saline control) received 2 ml/kg intraperitoneal (i.p.) normal saline with 10 distilled water orally, B, C and D (melatonin i.p. at 5, 20 mg/kg respectively. E (cyclophosphamide 150 mg/kg/day cyclophosphamide while group F standard drug, (erythropoietin 100 IU/kg. G, H I (treatment groups) orally. was administered days 1 only, oral administrations occur once daily for 14 days. On day 15, animals sacrificed blood collected cardiac puncture assessment parameters; white cell count (WBC), red (RBC) platelets (PLT). Results: The results showed a significant increase WBC D, G control; mg/kg. treatment; 5 mg/kg) (p=0.001) decrease compared to control). RBC increased significantly B decreased Compared control), F-I standard, treatment). PLT C, 5mg/kg treatment) (p=0.001). Conclusions: Melatonin has potential attenuate